Let’s delve into a significant topic.

While much of the media’s attention is directed toward GLP-1 medications such as Ozempic, licensed pharmacist Dr. Kati Forbes has brought attention to six commonly used medications that may contribute to weight gain.

One of the most unexpected culprits is a popular over-the-counter drug taken for allergic reactions.

1. Benadryl

Histamine, a chemical involved in the body’s immune response, plays a role in regulating appetite. According to the Obesity Medicine Association, antihistamines can disrupt the signals indicating fullness, which may lead to overeating.

Dr. Forbes explains that first-generation antihistamines like Benadryl and cyproheptadine, which is also prescribed to stimulate appetite, can result in weight gain, particularly with prolonged use.

2. Paroxetine (Paxil)

“Paroxetine, commonly known as Paxil, is recognized as one of the more sedative SSRIs (selective serotonin reuptake inhibitors) utilized for treating depression, anxiety, and OCD,” Dr. Forbes states.

This class of medications enhances serotonin levels in the brain, but Forbes identifies Paxil as one of the primary offenders in terms of weight gain, particularly as its use among young adults and teenagers has surged, according to recent trends.

A study found that approximately 14% of adults in the US are on antidepressants, and the Harvard Pilgrim Health Care Institute indicates that many discontinue their use due to weight gain.

Several psychiatrists at renowned New York hospitals have mentioned to The Post their reluctance to prescribe Paxil because it leads to more weight gain and sexual dysfunction compared to alternative medications, and its withdrawal symptoms can be quite severe.

3. Mirtazapine

Mirtazapine, marketed as Remeron, is frequently prescribed for individuals with PTSD or insomnia, and higher doses may be given for major depressive disorder.

“We generally avoid using this medication in patients with a higher body weight,” Dr. Forbes notes, adding that mirtazapine is also used in veterinary medicine as an appetite stimulant.

Dr. James Kocsis from Weill Cornell Medicine has previously stated to The Post that Remeron is frequently associated with weight gain due to its sedative effects. In a recent TikTok, Forbes suggests trazodone as a preferable option with fewer appetite-increasing effects.

4. Second-generation antipsychotics

Antipsychotic medications are used to manage conditions like psychosis and schizophrenia and are divided into two categories: first-generation and second-generation antipsychotics.

According to Forbes, second-generation antipsychotics—particularly Zyprexa and Seroquel—are known to significantly contribute to weight gain, with some patients gaining anywhere from 30 to 50 pounds within a year.

These medications influence neuropeptides, the signaling molecules related to appetite regulation and food consumption.

Forbes further explains that the weight gain associated with these drugs is tied to their antihistamine properties and their effects on serotonin receptors, particularly the 2C receptors.

5. Dronabinol

Dronabinol is a synthetic version of THC used mainly to help stimulate appetite in cancer patients experiencing nausea and vomiting after chemotherapy and in adults with HIV/AIDS who are facing weight loss.

6. Insulin

Dr. Forbes elaborates, “Insulin’s role is to transport glucose into cells rather than allowing it to remain in the bloodstream.” It’s essential to differentiate insulin from medications like Ozempic, Mounjaro, and Trulicity, which, although they are also injectable, function differently.

Although insulin aids in glucose absorption by cells, an excess of glucose absorbed can be converted into fat, leading to weight gain.

In addition to her pharmacy work, Dr. Forbes has shared her insights on her skincare products and discussed essential medications for managing cold and flu symptoms, as well as innovative uses for ineffective stool softeners in past articles.